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Nephrology News

New Drug Slows Advanced Kidney Cancer
Treating advanced kidney cancer patients with the drug pazopanib (Votrient) slowed their disease progression by 54 percent, a new study has found.The phase 3 study included 233 patients with previously untreated kidney cancer (also known as renal cell carcinoma) that was locally advanced or had spread, and 202 patients with renal cell carcinoma who had previously been treated with cytokine therapy (interferon or interleukin). The patients were randomly assigned to take pazopanib tablets (290 patients) or a placebo drug (145 patients).

Bypass Anemia Drugs in Chronic Kidney Disease, Expert Says
Anemia in most chronic kidney disease patients should be managed with iron supplements or blood transfusions, if anything, rather than erythrocyte-stimulating agents, a leading nephrologist has recommended. The only good case for long-term use of erythropoietin drugs in this population is in those who are transplant candidates or have severe anemia with a hemoglobin under 9 g/dl that cannot be managed with transfusions, Ajay K. Singh, of Harvard and Brigham and Women's Hospital in Boston, concluded.

Hospital Re-Admission High For Dialysis Patients Treated In Long-Term Care Hospitals
A new study by University of Cincinnati (UC) nephrologists shows that most dialysis patients admitted to long-term care hospitals face readmission to acute care facilities, and those with acute kidney failure don't often recover full kidney function. This study is being published in the advanced online edition of the American Journal of Kidney Diseases, the official journal of the National Kidney Foundation.

 

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Nephrology Articles

Erythropoiesis-Stimulating Agents β€” Time for a Reevaluation

Epoetin alfa was approved in 1989 by the Food and Drug Administration (FDA) for the treatment of anemia associated with chronic kidney disease β€œto elevate or maintain the red blood cell level . . . and to decrease the need for transfusions.” Although epoetin alfa and darbepoetin alfa, a related erythropoiesis-stimulating agent (ESA) approved in 2001, have been widely accepted for this indication, optimal hemoglobin targets have never been established........ Full Textimage

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