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A history of preeclampsia identifies women who have
underlying cardiovascular risk factors
American Journal of Obstetrics & Gynecology
January 28, 2009
A study
out in this months American Journal of Obstetrics & Gynecology
shines some light into connection between pre-eclampsia (PE), which is
defined as high blood pressure seen later in pregnancy and proteinuria,
as being an earliest indicator of a woman's risk of future
cardiovascular disease. It has been shown in previous studies that
patients whom develop PE have an increased risk of coronary
calcification, increased carotid artrey intimal wall thickness, and
metabolic syndrome.
This
study was done at Kingston and Ottawa General Hospital and included all
women diagnosed with PE (blood pressure greater than 140/90 mm Hg and
proteinuria greater then 300 mg per 24 hours or 2+ or greater on repeat
dipstick) at the time of presentation.
It was found that at 1 year postpartum, women who developed PE had increased blood pressure, total
cholesterol, higher LDL cholesterol, triglycerides, increased BMI, fasting
insulin.
The
data of this study suggested that the development of PE may be 1 of the
earliest identifiable risk markers of underlying cardiovascular risk
and potential future cardiovascular disease in women. It is still
unknown how much PE contributes to the cardiovascular risk factors, or
potentiates them and further studies need to be conducted that follow
patients before their first pregnancy and after birth.
Changes in management following these studies suggest that women who develop PE should have screening for cardiovascular
risk factors starting at 1 year after giving birth which could prevent long-term cardiovascular morbidity and mortality in
these women.
Read the Abstract |
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